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# Adjusted creatinine clearance

Anonymous
wrote...
2 months ago
 Adjusted creatinine clearance Sonata® (Zaleplon), a non-benzodiazepine hypnotic, is used for the short-term treatment ofinsomnia. The normaldose of Sonata® is 10 mg/day. From literature studies, it is known that10% of Sonata® is excreted unchanged in the urine. What will be the new adjusted dose ofSonata® for a female (55 kg) with creatinine clearance of 85 ml/min? Read 46 times 2 Replies

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Replies
Anonymous
wrote...
2 months ago
 Out of the 10 mg/day, 10% is excreted, which makes up 10(0.1) = 1 mg/day.Adjusted dose = Normal dose x (1 - % excretion) x (1 + renal adjustment factor)The renal adjustment factor is calculated based on the patient's creatinine clearance (CrCl), which reflects the patient's kidney function. The formula for renal adjustment factor is:Renal adjustment factor = 0.72 x (CrCl/50)Using the above formulas, we can calculate the adjusted dose of Sonata® as follows:Renal adjustment factor = 0.72 x (85/50) = 1.224Adjusted dose = 10 mg x (1 - 0.1) x (1 + 1.224) = 10 mg x 0.9 x 2.224 = 20 mgTherefore, the new adjusted dose of Sonata® for a female weighing 55 kg and with a creatinine clearance of 85 ml/min is 20 mg per day.
Gmill Author
wrote...
2 months ago
 Thank you.