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barry barry
wrote...
Posts: 11630
11 years ago
Polypeptides must be sorted after translation. Does protein sorting occur in both prokaryotes and eukaryotes? Describe the process of protein sorting and explain how the signal sequence is involved. What would you expect to see if the signal sequence has been mutated or deleted?
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wrote...
Educator
11 years ago
Protein sorting is a process that uses signal sequences of amino acids at the N-terminal end of a polypeptide to sort proteins and direct them to their cellular destinations.

Protein sorting is needed in bacterial cells because of the many proteins specifically destined for the cell membrane. In eukaryotes, however, protein sorting is far more complex than in bacteria; proteins are dispatched to particular cellular organelles, such as the chloroplast, mitochondrion, lysosome, and nucleus, and certain proteins are secreted from the cells. If the signal sequence is mutated, proteins may not be secreted or processed properly and will begin to accumulate within the cell. Ultimately, this will result in cell death and impaired protein secretion.
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