Explain the kiss-and-run model of synaptic vesicle exocytosis, and how it differ

ppk

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12 years ago

Explain the kiss-and-run model of synaptic vesicle exocytosis, and how it differ

Explain the kiss-and-run model of synaptic vesicle exocytosis, and how it differs from the classic model.

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shruti

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12 years ago

The classical model of synaptic-vesicle recycling
after neurotransmission involves the retrieval of membrane at a distant location from the active zone (which is where secretion of neurotransmitters occurs), and fusion of the internalized membrane with an endosome-like compartment1,3. An alternative model, the ‘kiss-and-run’ hypothesis, proposes that synaptic vesicles may transiently
fuse with the plasma membrane and release their contents
through a partially open fusion pore without merging of vesicle and plasma membrane.

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shruti

wrote...

12 years ago

The classical model of synaptic-vesicle recycling after neurotransmission involves the retrieval of membrane at a distant location from the active zone (which is where secretion of neurotransmitters occurs), and fusion of the internalized membrane with an endosome-like compartment. An alternative model, the ‘kiss-and-run’ hypothesis, proposes that synaptic vesicles may transiently
fuse with the plasma membrane and release their contents
through a partially open fusion pore without merging of vesicle and plasma membrane.

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duddy

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Staff Member

12 years ago

Quote from: shruti (12 years ago)

The classical model of synaptic-vesicle recycling after neurotransmission involves the retrieval of membrane at a distant location from the active zone (which is where secretion of neurotransmitters occurs), and fusion of the internalized membrane with an endosome-like compartment. An alternative model, the ‘kiss-and-run’ hypothesis, proposes that synaptic vesicles may transiently
fuse with the plasma membrane and release their contents
through a partially open fusion pore without merging of vesicle and plasma membrane.

Great explanation, please mark this as solved PPK.

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