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anon41429384 anon41429384
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7 years ago
how verapamil, acting as a calcium channel blocker, might act on the contractile cells of the left ventricle of the heart to reduce arterial blood pressure. Be sure to explain specifically where (what cells) and how (what happens, step-by-step) verapamil, as calcium channel blocker, ‘works’ at a cellular level to affect the work of the specific cells of the heart and how, in turn, this decreases arterial blood pressure. 
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7 years ago
As with many medications, the exact mechanism of action of Transdermal Verapamil 15% Gel is not entirely understood. It is proposed that two different processes are taking place. The first allows for the progression of the lesion to be slowed or stopped and second for the lesion to actually be reduced, which allows for the symptoms of the condition to be reduced or eliminated. Both of these processes are effected by verapamil's ability as a calcium channel blocker to block calcium.

Cells known as fibroblasts are responsible for the production of the primary components of the lesion such as collagen, fibronectin and glycosaminoglycans. Research has shown that the process by which these components are released out of the fibroblast requires calcium. [1] It has been found that calcium channel blockers have the ability to decrease the production of collagen and fibronectin and their release from the fibroblast. [2] A study has also shown that the large increase of Peyronie's fibroblasts is markedly impaired by verapamil, even at low doses. [3] This research is the basis of why it is thought that using Transdermal Verapamil 15% Gel in the inflammatory or early stages of these fibrotic tissue disorders, may prevent the condition from being as severe as it might have been without any treatment.

Fibroblasts are also responsible for the production of collagenase, which is responsible for remodeling the excess collagen that makes up the lesion. Research has demonstrated that calcium channel blockers such as verapamil have the ability to increase the activity of collagenase, which enhances the remodeling of scars in burn victims. [4] It was also found in experiments with bovine fibroblasts that exposure to verapamil increased collagenase activity. [5] Peyronie's disease, plantar fibromatosis, and Dupuytren's disease are thought to be similar to other wound disorders such as keloids and hypertrophic scars. Research on the use of verapamil in keloids has suggested that it may increase procollagenase production, meaning that verapamil may be capable of increasing collagen breakdown. [6] Although this research was not done on fibroblasts from Peyronie's disease, plantar fibromatosis, or Dupuytren's disease, it is theorized that fibroblasts from these lesions will respond in a similar way. This theory is supported by objectively measured improvements in Peyronie's disease plaque and plantar fibromatosis in clinical studies with Transdermal Verapamil 15% Gel. The increase in collagenase activity after exposing the fibroblasts to verapamil, helps to explain how Transdermal Verapamil 15% Gel can remodel an already formed and stable lesion into more healthy and elastic tissue. The remodeling of the tissue and return of the elasticity allows for the symptoms of the condition to be reduced or eliminated.

Source  1) http://www.pdlabs.net/healthcare_professionals/whatistvgel_hp.html
2) https://www.drugs.com/pro/verapamil.html
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