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minjai0322 minjai0322
wrote...
13 years ago
List two of the cofactors involved in the reaction catalyzed by pyruvate dehydrogenase. What is a cofactor of an enzyme?
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Educator
13 years ago
Pyruvate dehydrogenase (E1) performs the first two reactions within the pyruvate dehydrogenase complex (PDC): a decarboxylation of substrate 1 (pyruvate) and a reductive acetylation of substrate 2 (lipoic acid). Lipoic acid is covalently bound to dihydrolipoamide acetyltransferase (E2), which is the second catalytic component enzyme of PDC.

More information can be found here...

http://rpi.edu/dept/bcbp/molbiochem/MBWeb/mb1/part2/11-krebs.ppt
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