Protein cleaving

Under which one of the following conditions would the signal peptide of a protein be cleaved off by signal peptidase?

1.If a transmembrane protein's N-terminus is in the cytoplasm, its C-terminus in the lumen, and it crosses the membrane 3 times
2. If a transmembrane protein's N-terminus is in the lumen, its C terminus in the cytoplasm, and it crosses the membrane once
3. If a transmembrane protein's N-terminus is in the cytoplasm and the C-terminus is in the luman and it crosses the membrane once
4. If a transmembrane protein's N and C-termini are in the cytoplasm and it crosses the membrane twice
5. If a transmembrane protein has its N- and C-termini in the cytoplasm and it crosses the membrane four times