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oemBiology oemBiology
wrote...
Posts: 1245
6 years ago
I would like to know on what kind of food can remove extra chromium (heavy metal) within body.

Does anyone have any suggestions?
Thanks in advance for any suggestions
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wrote...
Educator
6 years ago
Building on your previous thread, I found a scientific journal that explains the chelation of chromium.

According to the article (link provided below):

Ascorbic acid appears to have time-dependent mortality benefits. Given early, it appears to show a benefit; provision only 3 hours later showed harm. It also has the potential for a time-dependent risk–benefit profile: late administration could potentially cause harm and therefore is generally not recommended.

Chromium Chelators and Chelation Considerations

Chromium(VI) is particularly problematic as a toxic exposure. It probable acts following reduction to chromium(V) intermediate species, which can generate reactive oxygen species (ROS) through a Fenton-like reaction [97]. Treatment strategies could then approach two potential mechanisms. Either chromium(VI) would require successful chelation, or sufficient reductants must be provided in order to achieve chromium(III) safely and avoid ROS production. Several such strategies have been evaluated in humans. Many of these are provided as case reports of patients who ingested chrome salts or were exposed in industry or via prostheses. BAL essentially has no effect on chromium elimination [100, 103]. EDTA yielded essentially uninterpretable increases in urinary elimination over 48 hours in one study that was significantly methodologically compromised [104]. Two other reports utilizing EDTA failed to show any benefit in increasing urinary elimination [105, 106]. A DMPS challenge failed to show any increase in chromium excretion [107]. As adjuvant therapy in patients who were exposed, NAC did not demonstrate any particular benefit, although it was without apparent toxicity [102, 108].

What else can be attempted in an ill, exposed patient? Exchange transfusion is extremely heroic, but might have some benefit [101]. The data regarding the effectiveness of hemodialysis are mixed; it also may be instituted for concurrent renal failure [101, 102, 109, 110]. Ascorbic acid has been added as a nonspecific antioxidant in addition to multiple therapeutic measures, making determination of its individual contribution difficult in humans [101, 108].

Animal experiments have evaluated a range of agents. Ascorbic acid appears to have time-dependent mortality benefits. Given early, it appears to show a benefit; provision only 3 hours later showed harm [111]. Theoretically, ascorbate could precipitate acute oxalate nephropathy. The use of alpha-lipoic acid resulted in no change in urinary clearance [112]. BAL has generally been unsubstantiated in having any benefit in increasing either urinary or fecal clearance [100, 112]. While DFO appeared promising in a pre-exposure model, in a post-exposure model, it was entirely ineffective [113]. d-Penicillamine decreased excretion and was actually harmful in terms of urinary clearance [112]. EDTA showed no benefit [112]. In one animal study, which is particularly referenced, NAC did show an increase in urinary chromium clearance. Of note, this was not due to any increase in concentration in the urine, but rather due to maintenance of the critical factors of adequate urine volume and output [114]. NAC did reduce chromium hypersensitivity dermatological reaction [115].

Section Summary

Significant chromium species differences exist. Reducing ongoing exposure to any chromium source must be rigorously addressed in the setting of chromium toxicity. There is little evidence to suggest that currently available chelators are efficacious. NAC could be considered on the basis of anecdotal human use and limited animal evaluation. It does have a familiar risk/benefit profile. Ascorbic acid has anecdotal human use. However, it also has the potential for a time-dependent risk–benefit profile: late administration could potentially cause harm and therefore is generally not recommended.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3846962/

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