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Home Q & A Board Biology-Related Homework Help Cell Biology
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dacaol dacaol
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10 years ago
Considering the nature of Listeria moncytogenes, why can’t you simply run an anti-Listeria antibody screen to determine infection with this pathogen?

I know that the pathogen has an intracellular life cycle so Is this the reason the anitbody screen wont work?

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#1
Educator
10 years ago
From what I remember, L. moncytogenes prevents an immune response from developing by escaping MHC class II presentation on antigen-presenting cells (look at the diagram below). As a result, the bacteria never gets digested inside the B-cells and dendritic cells that ingest it in order for its antigens to be presented.



Source:

http://www.ppdictionary.com/bacteria/gpbac/listeria.htm

Hope this helps...
dacaol Author
wrote...
#2
10 years ago
Yes, This is very helpful.  Grinning Face
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