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Home Q & A Board Biology-Related Homework Help Genetics and Developmental Biology
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morgan795 morgan795
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Posts: 16
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8 years ago
Sickle-cell disease is caused by a mutation that changes a single codon of the b-globin gene from 5’-GAG (encoding glutamic acid) to 5’-GTG (encoding valine).  Heterozygotes have a distinct phenotype involving malaria resistance.  Which of the following terms apply to this mutation?
Select all that applies
A) synonymous (or silent) mutation
B) missense mutation
C) nonsense mutation
D) frameshift mutation
E) null (or loss-of-function) mutation
F) transversion
G) indel mutation
H) neomorphic (or gain-of-function) mutation
I) transition
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#1
Educator
8 years ago
In genetics, a missense mutation (a type of nonsynonymous substitution) is a point mutation in which a single nucleotide change results in a codon that codes for a different amino acid.

So, B

Quote from: morgan795 (8 years ago)
E) null (or loss-of-function) mutation

Would also say this Upwards Arrow
wrote...
#2
8 years ago
Quote from: bio_man (8 years ago)
In genetics, a missense mutation (a type of nonsynonymous substitution) is a point mutation in which a single nucleotide change results in a codon that codes for a different amino acid.

So, B

Quote from: morgan795 (8 years ago)
E) null (or loss-of-function) mutation

Why would not be frameshit too?
Would also say this Upwards Arrow
wrote...
#3
Educator
8 years ago
Upwards Arrow ?
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