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fareh fareh
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10 years ago
what is         exon shuffling       and        what are the mechanisms of exon shuffling?   Slight Smile
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Staff Member
Educator
10 years ago
Exon shuffling is when genes that code for more then one protein exchange domains, coding for new multi-domain proteins.

For example, We have 3 sentences.

1) The dog went to the store.
2) I told him to stay at home.
3) The weather is nice,however.

I can switch the order of these sentences into 2 3 1,or 1 2 3, or 3 2 1,etc.
Mastering in Nutritional Biology
Tralalalala Slight Smile
wrote...
10 years ago
Exon shuffling is a molecular mechanism for the formation of new genes. It is a process through which two or more exons from different genes can be brought together ectopically, or the same exon can be duplicated, to create a new exon-intron structure.

There are different mechanisms through which exon shuffling occurs: transposon mediated exon shuffling, crossover during sexual recombination of parental genomes and illegitimate recombination.

Exon shuffling follows certain splice frame rules. Introns can interrupt the reading frame of a gene by inserting a sequence between two consecutive codons (phase 0 introns), between the first and second nucleotide of a codon (phase 1 introns), or between the second and third nucleotide of a codon (phase 2 introns). Additionally exons can be classified into nine different groups based on the phase of the flanking introns (symmetrical: 0-0, 1-1, 2-2 and asymmetrical: 0-1, 0-2, 1-0, 1-2, etc.) Symmetric exons are the only ones that can be inserted into introns, undergo duplication, or be deleted without changing the reading frame.
fareh Author
wrote...
10 years ago
so, it has 3   (Crossover during sexual recombination of parental genomes/Transposon mediated/Illegitimate recombination) mechanisms or 2 mechanisms (Crossover / Transposon mediated) Neutral FaceNeutral FaceNeutral Face??
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