Definition for Sickle-cell anemia
From Biology Forums Dictionary
1) A disease caused by a genetic mutation in a hemoglobin gene in which sickle-shaped red blood cells are less able to move smoothly through capillaries and can block blood flow, resulting in severe pain and cell death of the surrounding tissue.
2) A genetic disorder in which erythrocytes take on an abnormal curved or “sickle” shape. These cells are fragile and are easily damaged, leading to a hemolytic anemia.