Definition for Deplete

Dependent variable

Depletion curves

To reduce in amount by using up.

For example, years of farming on the same small plot of land had left the soil depleted of minerals. 

The de- prefix often means "do the opposite of," so deplete means the opposite of "fill". It can mean merely a lessioning in amount; thus, food supplies can be rapidly depleted by hungry teenagers in the house.

See also: Replete