Definition for Aspartate transcarbamoylase

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The "hemoglobin of enzymology", ATCase is the most extensively-studied example of an allosteric enzyme. The enzyme from E. coli is a dodecamer consisting of six catalytic subunits and six regulatory subunits. ATCase catalyzes the first step in pyrimidine biosynthesis, namely the addition of carbamoyl phosphate to L-aspartate to form N-carbamoylaspartate and phosphate.