Section 3 - Receptors

Click to edit Master title style Click to edit Master text styles Second level Third level Fourth level Fifth level Click to edit Master title style Click to edit Master text styles Second level Third level Fourth level Fifth level Click to edit Master text styles Second level Third level Fourth level Fifth level Principles of Pharmacology and Toxicology (BIOL3020) Section 3 Receptors Rang et al 2007 (Chapter 3) Receptors There are four types of receptors which drugs can act Receptors in more detail There are four types of receptors which drugs can act Type 1 Ligand-gated ion channels c  Action Potential Na acetylcholine Presynaptic neuron Postsynaptic neuron Nicotinic acetylcholine receptor Depolarization and possible Action Potential The Nicotinic Acetylcholine Receptor s  M1 M2 M3 M4 The Nicotinic Acetylcholine Receptor M1 M2 M3 M4 M2 The Nicotinic Acetylcholine Receptor The Nicotinic Acetylcholine Receptor Another view of the Acetylcholine Receptor Mechanism of Activation Z Z Another view of the gate Atsuo Miyazawa, Yoshinori Fujiyoshi and Nigel Unwin (2003) Nature Other ligand-gated ion channels Receptors for some other fast transmitters, include the GABAA receptor channel the 5-HT3- (serotonin) receptor channel the glycine receptor channel. These are built on the same pattern as the nicotinic acetylcholine receptor  Other ligand-gated ion channels have similar structure However, chloride channels such as the GABA channel have differences Drugs and Toxins that effect ligand-gated ion channels (Antagonists) Drugs and Toxins that effect ligand-gated ion channels (Agonists) 5   GPCR Signaling G-proteins GPCR Signaling 1  GPCR Signaling the G-proteins diffuse in the membrane and can activate or inhibit various targets (eg. enzymes and ion channels) GPCR Signaling GPCRs can be stimulatory or inhibitory  muscarinic - AC What is adenylate cyclase (AC) So what does cAMP do  Not only involved in regulating heart contraction involved in glycogen metabolism in liver The agonist here is adrenaline (epinephrine) http //carbon.cudenver.edu/ bstith/camp.mov Other targets for G-proteins