The Trace Minerals.docx

The Trace Minerals “Of special interest to...” symbol key: = Hot Topic = Personal Health = Health Care Professionals = Science Majors The Trace Minerals—An Overview Trace minerals are needed in very small quantities in the human body. They perform many essential functions important to health. Toxic levels can easily be reached with the use of supplements. Humans can get the amounts of trace minerals needed by consuming a wide variety of foods. A. Food Sources Depends on soil and water composition Depends on processing Bioavailability Wide variety of foods B. Deficiencies Mild deficiencies are easily overlooked. Severe deficiencies are easy to recognize. Deficiencies have wide-reaching effects. Affects all ages C. Toxicities A person should not exceed Upper Level Recommended Intakes. A person should not exceed 100% Daily Values. FDA does not limit amounts in supplements. Interactions Common and coordinated to meet body needs Can lead to nutrient imbalances Iron Iron is found in the body as part of the oxygen-binding proteins hemoglobin and myoglobin. Iron is used for energy metabolism and enzyme activity. Special proteins assist with iron absorption, transport, and storage. Both iron deficiency and iron toxicity cause damage so balance is important. Heme iron is better absorbed but nonheme iron absorption can be enhanced. A. Iron Roles in the Body Ferrous iron is reduced and has a net positive charge of two. Ferric iron is oxidized and has a net positive charge of three. Cofactor in oxidation-reduction reactions Part of the protein hemoglobin which carries oxygen in the blood Part of the protein myoglobin in the muscles which makes oxygen available for muscle contractions Utilization of energy in cell metabolism B. Iron Absorption and Metabolism Iron Absorption The protein ferritin stores iron in the mucosal cells. The mucosa is the lining of the digestive tract. Transfers iron to mucosal transferrin. Transfers iron to blood transferrin Transports iron to the cells Excreted and replaced as needed Heme and Nonheme Iron Heme iron Foods that are flesh of animals 10% of days consumption Absorption rate of 25% Nonheme iron Plant-derived and animal-derived foods Absorption rate of 17% Absorption-Enhancing Factors MFP factor Vitamin C Citric acid and lactic acid from foods HCl from stomach Sugars Absorption-Inhibiting Factors Phytates and fibers from grains and vegetables Oxalates from spinach, beets and rhubarb Calcium and phosphorus from milk EDTA (food additive) Tannic acid and other polyphenols in tea and coffee Dietary Factors Combined Difficult to assess with meal consumption Most relevant factors are MFP factor, Vitamin C and phytates Individual Variation Dietary factors Health status Stage in life cycle Iron status Iron Transport and Storage Surplus is stored in bone marrow, spleen, and liver Hemosiderin is a storage protein used when concentrations of iron are extremely high. Storing excess iron is a protective measure because iron can act as a free radical. Iron Recycling Liver and spleen dismantle red blood cells and package iron into transferrin. Transferrin carries iron in the blood. Bone marrow incorporates iron into hemoglobin and stores iron as ferritin. Iron-containing hemoglobin carries oxygen in the blood. Iron is lost with bleeding and through the GI tract. C. Iron Deficiency Vulnerable Stages of Life Women in reproductive years Pregnant women Infants and young children Teenagers Blood Losses Giving a pint of blood loses about 2.5 mg iron Menstruation Bleeding ulcers Malaria and parasites Assessment of Iron Deficiency Stage 1 - Iron stores diminish; measure serum ferritin Stage 2 – Transport iron decreases; measure transferrin saturation Stage 3 – Hemoglobin production declines; erythrocyte protoporphyrin accumulates and hematocrit declines Iron Deficiency and Anemia Iron deficiency is depleted iron stores. Iron-deficiency anemia is the severe depletion of iron stores. Also called microcytic hypochromic anemia. Symptoms include fatigue, weakness, headaches, apathy, pallor and poor resistance to cold temperatures. Iron Deficiency and Behavior Energy metabolism is impaired. Neurotransmitter synthesis is reduced. Physical work capacity is reduced. Mental productivity is reduced. Iron Deficiency and Pica Habit of eating ice, clay, paste, and other nonfood substances Generally in women and children from low-income groups D. Iron Toxicity Iron Overload Hemochromatosis is generally a genetic disorder that enhances iron absorption. Repeated blood transfusions Massive doses of supplemental iron May cause hemosiderosis Symptoms include apathy, lethargy, and fatigue Problems include liver tissue damage and infections Higher risk of diabetes, liver cancer, heart disease, and arthritis Iron and Heart Disease – may be a link to high iron stores Iron and Cancer – may be a link with free radical activity Iron Poisoning Upper level for adults: 45 mg/day Accidental supplement poisoning in children Symptoms include nausea, vomiting, diarrhea, constipation, rapid heartbeat, weak pulse, dizziness, shock, and confusion E. Iron Recommendations and Sources Recommended Intakes (2001 RDA) RDA Men: 8 mg/day for adults 19-50 years of age RDA Women: 18 mg/day for adults 19-50 years of age RDA Women: 8 mg/day for adults over 51 years of age Vegetarians needs 1.8 times as much iron because of low bioavailability. Iron in Foods Red meats, fish, poultry, and shellfish Eggs Legumes Dried fruits Iron-Enriched Foods Often added to grain foods Not absorbed as well Maximizing Iron Absorption Bioavailability is high in meats, fish, and poultry. Bioavailability is medium in grains and legumes. Bioavailability is low in vegetables. Combined effect of enhancing and inhibiting factors Iron Contamination and Supplementation Contamination Iron Iron cookware takes up iron salts Acidic foods and long time cooking increase uptake of iron salts Iron Supplements Best absorbable form is ferrous sulfate or an iron chelate Take on empty stomach and with liquids other than milk, tea, or coffee Vitamin C enhances food iron absorption not supplement absorption Side effect of constipation Zinc Zinc is important in a multitude of chemical reactions in the body. The best sources of dietary zinc are protein-rich foods. Zinc from pancreatic secretions is also available for absorption. Phytates and fiber can bind zinc, therefore limiting absorption. A special binding protein monitors the absorption of zinc. Zinc deficiency symptoms include growth retardation and sexual immaturity. A. Zinc Roles in the Body Supports the work of metalloenzymes Helps to make parts of DNA and RNA Manufactures heme for hemoglobin Assists in essential fatty acid metabolism Releases Vitamin A from liver stores Metabolizes carbohydrates Synthesizes proteins Metabolizes alcohol Disposes damaging free radicals Affects platelets in blood clotting and wound healing Affects thyroid hormone function Influences behavior and learning performance Taste perception Sperm development Fetal development B. Zinc Absorption and Metabolism Zinc Absorption Rate of absorption depends on zinc status Phytates and fiber bind zinc and reduce absorption. Metallothionein is a special protein that holds zinc in storage. Zinc Recycling Enteropancreatic circulation Losses occur in the feces. Zinc Transport Transported by the protein albumin Binds to transferrin C. Zinc Deficiency Not widespread Occurs in pregnant women, young children, the elderly, and the poor Symptoms of deficiency Growth retardation Delayed sexual maturation Impaired immune function Hair loss, eye and skin lesions Loss of appetite D. Zinc Toxicity Upper Level for Adults: 40 mg/day Symptoms Loss of appetite Impaired immunity Low HDL Copper and iron deficiencies Vomiting and diarrhea Exhaustion Headaches E. Zinc Recommendations and Sources Recommended Intakes (2001 RDA) RDA Men: 11 mg/day RDA Women: 8 mg/day Zinc in Foods Red meats and shellfish Whole grains Zinc Supplementation Developing countries use zinc to reduce incidence of disease and diarrhea. Zinc lozenges for the common cold are controversial and inconclusive. Iodine Iodide is an essential component of the thyroid hormone that helps to regulate metabolism. Iodine deficiency can cause simple goiter and cretinism. The iodization of salt has eliminated iodine deficiency in the United States and Canada. Iodide Roles in the Body Component of two thyroid hormones Regulates growth, development, and metabolic rate Iodine Deficiency Simple goiter is the enlargement of the thyroid gland caused by iodine deficiency. Goiter is enlargement of the thyroid gland due to malfunction of the gland, iodine deficiency or overconsumption of goitrogens. Cretinism is a congenital disease characterized by mental and physical retardation and commonly caused by maternal iodine deficiency during pregnancy. Goitrogen overconsumption– naturally occurring in cabbage, kale, brussels sprouts, cauliflower, broccoli, and kohlrabi Iodine Toxicity Upper level 1000 g/day Symptoms include underactive thyroid gland, elevated TSH, and goiter Supplement use, medications, and excessive iodine from foods Iodine Recommendations and Sources Recommendations (2001 RDA) Adults: 150 g/day Sources Iodized salt Seafood Bread and dairy products Plants grown in iodine-rich soils Animals that feed on plants grown in iodine-rich soils Selenium Selenium is an antioxidant nutrient associated with protein foods. It may provide some protection against certain types of cancer. Selenium Roles in the Body Defends against oxidation Regulates thyroid hormone Selenium Deficiency Keshan disease – a pre-disposition to heart disease where cardiac tissue becomes fibrous Prevalent in regions of China Selenium and Cancer May protect against certain forms of cancer Inconclusive evidence and more research is needed Food sources are better than supplements Selenium Recommendations and Sources Recommendations (2000 RDA) Adults: 55 g/day Sources include seafood, meat, whole grains, and vegetables (depends on soil content) Selenium Toxicity Upper Level for Adults: 400 g/day Symptoms Loss and brittleness of hair and nails Skin rash, fatigue, irritability, and nervous system disorders Garlic breath odor Copper Copper is a component of several enzymes associated with oxygen or oxidation. Copper deficiency is rare. There are some diseases associated with excessive intakes. Food sources of copper include legumes, whole grains, and seafood. Copper Roles in the Body Absorption and use of iron in the formation of hemoglobin Part of several enzymes Some copper containing enzymes are antioxidants. Copper Deficiency and Toxicity Deficiency symptoms include anemia and bone abnormalities. Menkes disease Toxicity Upper Level for Adults: 10,000 g/day (10 mg/day) Wilson’s disease Copper Recommendations and Sources Recommendations (2001 RDA) Adults: 900 g/day Sources Seafood, nuts, seeds and legumes Whole grains Manganese Manganese is a cofactor for several enzymes involved in bone formation and various metabolic processes. Deficiencies are rare and toxicities are associated with environmental contamination. Manganese is found widespread in foods. Manganese Roles in the Body Cofactor for several enzymes Assists in bone formation Pyruvate conversion Manganese Deficiency and Toxicity Deficiency symptoms are rare Phytates, calcium and iron limit absorption. Toxicity occurs with environmental contamination. Upper Level for Adults: 11 mg/day Toxicity symptoms include nervous system disorders. Manganese Recommendations and Sources Recommendations (2001 AI) AI Men: 2.3 mg/day AI Women: 1.8 mg/day Sources Nuts Whole grains Leafy vegetables Tea Fluoride Fluoride makes bones stronger and teeth more resistant to decay. The use of fluoridated water can reduce dental caries. Excess fluoride causes fluorosis—the pitting and discoloration of teeth. Fluoride Roles in the Body Formation of teeth and bones Helps to make teeth resistant to decay Fluorapatite is the stabilized form of bone and tooth crystals B. Fluoride and Dental Caries Widespread health problem Leads to nutritional problems C. Fluoride and Toxicity Tooth damage called fluorosis Upper Level for Adults: 10 mg/day Prevention of fluorosis Monitor fluoride content of local water supply. Supervise toddlers during tooth brushing. Watch quantity of toothpaste used (pea size) for toddlers. Use fluoride supplements only if prescribed by a physician. Fluoride Recommendations and Sources Recommendations (1997 AI) AI Men: 3.8 mg/day AI Women: 3.1 mg/day Sources Fluoridated drinking water Seafood and tea Chromium Chromium enhances insulin’s action. It is widely available in unrefined foods. Chromium Roles in the Body Enhances insulin action Glucose tolerance factors (GTF) are small organic compounds that enhance insulin’s action Chromium Recommendations and Sources Recommendations (2001 AI) AI Men: 35 g/day AI Women: 25 g/day Sources Meat, especially liver Whole grains Brewer’s yeast Chromium Supplements Do not effectively improve glucose or insulin response in diabetics Claims about reducing body fat and improving muscle strength remain controversial. Molybdenum Molybdenum is a cofactor in several enzymes. It is needed in minuscule amounts. It is available in legumes, grains, and organ meats. Molybdenum functions as a cofactor for several enzymes. No deficiency symptoms No reported toxicity symptoms Recommendations (2001 RDA) Adults: 45 g/day Upper Level Adults: 2 mg/day Food sources include legumes, grains, and organ meats. Other Trace Minerals Much of the research on other trace minerals is from animal studies. Humans need very small amounts. Determining exact needs, functions, deficiencies, and toxicities is difficult. Some key roles of these other trace minerals have been identified. Nickel is a cofactor for certain enzymes. Silicon is used in bone and collagen formation. Vanadium is for growth, development, and normal reproduction. Cobalt is a key component of Vitamin B12. Boron may be key in brain activities. Arsenic is useful in some types of leukemia. Contaminant Minerals Contaminate minerals are also called heavy metals. These include mercury, lead, and cadmium. These minerals enter the food supply through soil, water, and air pollution. They disrupt body processes and impair nutrition status. A. Lead Toxicity Symptoms in Children Learning disabilities in children Low IQ Behavior problems Slow growth Dental caries Iron-deficiency anemia Sleep disturbances like night walking, restlessness, and head banging Nervous system disorders and seizures Slow reaction time and poor coordination Impaired hearing Lead Toxicity Symptoms in Adults Hypertension Reproductive complications Kidney failure Highlight: Phytochemicals and Functional Foods Phytochemicals are nonnutrient compounds. Only a few of the thousands of phytochemicals have been researched. There are many questions and few answers about their role in human health. Foods that provide health benefits beyond those of nutrients are now called functional foods. Some have an identified role in disease prevention. A. The Phytochemicals Defending against Cancer Phytoestrogens mimic estrogen Antioxidant activity Slow the growth of breast and prostrate cancer Found in soybeans, flaxseed oil, whole grains, fruits and vegetables Lycopene Powerful antioxidant Inhibit the growth of cancer cells Found in tomatoes and cooked tomato products, apricots, guava, papaya, pink grapefruits, and watermelon Five servings of fruits and vegetables are recommended every day. Defending against Heart Disease Flavonoids in foods Powerful antioxidants Protect against LDL cholesterol oxidation and reduce blood platelet stickiness Lowers risk of chronic diseases Found in whole grains, legumes, soy, vegetables, fruits, herbs, spices, teas, chocolate, nuts, olive oil, and red wines Carotenoids in foods especially lutein and lycopene Lower risk of heart disease Found in fruits and vegetables Phytosterols May protect against heart disease Inhibit cholesterol absorption Lower blood pressure Act as antioxidants Found in soybeans and other vegetables Lignans, found in flax seed, are converted to phytosterols by intestinal bacteria. The Phytochemicals in Perspective Difficult to assess one food and its benefits alone Actions of phytochemicals are complementary and overlapping B. Functional Foods Foods as Pharmacy Yogurt and probiotics Margarine enhanced with a phytosterol may lower cholesterol. May be more useful in prevention and mild cases of disease. Drugs are used for severe cases of disease. Unanswered Questions Research is lagging behind food manufacturers. Consumer questions to ask Does it work? How much does it contain? Is it safe? Is it healthy? Future Foods Use of gene research Can we design foods to meet exact health needs of each individual? 3. Can farmers grow the “perfect” foods?