Top Posters
Since Sunday
I
3
3
p
2
w
2
y
2
J
2
Q
2
r
2
o
2
e
2
j
2
d
2
SlideshowReport

GTP Cycle

Description
RAS-family proteins are low-molecular-weight guanine-nucleotide-binding proteins. They are inactive when bound to GDP and active when bound to GTP. Regulation of this molecular switch mechanism occurs through a GDP–GTP cycle that is controlled by the opposing activities of guanine nucleotide-exchange factors (GEFs), which catalyse the exchange of GDP for GTP, and GTPase-activating proteins (GAPs), which increase the rate of GTP hydrolysis to GDP (see diagram). In the case of RHO proteins, another layer of regulation is provided by RHO–GDP-dissociation inhibitors (RHOGDIs), which sequester RHO away from the GDP–GTP cycle. GTPases interact with various effector proteins, which influence the activity and/or localization of these effectors; this ultimately influences cell-cycle progression.
Related Images
Commenting on this item has been disabled by the author or forum moderator.
Explore
Post your homework questions and get free online help from our incredible volunteers
  360 People Browsing
Show Emoticons
:):(;):P:D:|:O:?:nerd:8o:glasses::-):-(:-*O:-D>:-D:o):idea::important::help::error::warning::favorite:
Your Opinion
What percentage of nature vs. nurture dictates human intelligence?
Votes: 437