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Types of cell adhesion molecules (CAMs)

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Cadherins and integrins are CAMs that form connections in anchoring junctions. (a) A cadherin in one cell binds to a cadherin of an identical type in an adjacent cell. This binding requires Ca2+. In the cytosol, cadherins bind to actin or intermediate filaments of the cytoskeleton. (b) Integrins link cells to the extracellular matrix and form intracellular connections to actin or intermediate filaments.
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