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Structure and function of the Na+/K+ pump.

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(a) Active transport by the Na+/K+ pump. Each time this protein hydrolyzes one ATP molecule, it pumps out three Na and pumps in two K+. (b) Reaction mechanism. The figure illustrates the protein conformational changes between E1 and E2. As this occurs, ATP is hydrolyzed to ADP and phosphate. During the reaction mechanism, phosphate is covalently attached to the protein but is released after potassium ions bind.
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