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Biosynthesis of the lipid-linked oligosaccharide intermediate

Description
The five sequential mannosyl transfer reactions from GDP-mannose are catalyzed by separate glycosyltransferases, as are the four mannosyl transfers from dolichol phosphate mannose.

The latter is synthesized in turn from GDP-mannose. The acceptor site on the polypeptide chain is an asparagine residue two positions to the N side of a serine or threonine.

The whole process occurs in the endoplasmic reticulum, with translocation to the lumen of the ER occurring after transfer of the fifth mannose residue.
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