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SlideshowReport

Regulation of liver hexokinase by protein–protein interactions

Description
Activity of the liver hexokinase isozyme IV (HKIV) is regulated by alternative protein–protein interactions with the glucokinase regulatory protein (GKRP) in the nucleus and dephosphorylated PFK- 2/FBPase-2 in the cytoplasm.

Insulin binding to its plasma membrane receptor stimulates dephosphorylation of PFK-2/FBPase-2. Glut2, plasma membrane glucose transporter.
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