Examples of Personalized Medicine Drugs and Diagnostics

Examples of Personalized Medicine Drugs and Diagnostics
Therapy
Herceptin ® (trastuzumab)
Erbitux® (cetuximab)
Gleevec® (imatinib)
Gleevec® (imatinib)
Tarceva® (erlotinib)
Drugs/surgery
Hormone/chemotherapies
Chemotherapies
Rituximab
Gene Test
HERVZ amplification
ECFR expression, KVRAS mutations
BCR/ABL Fusion
C-KIT
EGFR expression
MLH7, MSHZ, M$H6
Oncotype DX‘E7 test
Aviara Cancer TYPE ID®
PGx Predict®
Description
Breast cancer test to accompany Herceptin use
Protein and mutation analysis prior to treatment
Gleevec used in treatment of Philadelphia chromosome-
positive chronic myelogenous leukemia
Gleevec used in stomach cancers expressing mutated
C—KIT
Lung cancer for EGFR-positive tumors
Gene mutations related to colon cancers
Selection oFbreast cancer patients For chemotherapy
Classifies 39 tumor types using gene-expression assays
Detects CD-ZO variants that predict response to ritux-
imab in non-Hodgkin lymphoma