The distribution of malaria and of the hemoglobin variants beta S and beta E.

(a) Regions of the world where malaria is endemic are shown. (b) The frequency distribution of the beta S allele in Africa, Southern Europe, the Middle East, and the Indian subcontinent. (c) The frequency distribution of the beta E allele in Southeast Asia and the Pacific Islands(a) Regions of the world where malaria is endemic are shown. (b) The frequency distribution of the beta S allele in Africa, Southern Europe, the Middle East, and the Indian subcontinent. (c) The frequency distribution of the beta E allele in Southeast Asia and the Pacific Islands

I Areas with endemic falciparum malaria 0)) Population percentage of the fi’allele ->14 .6—8 .1244 [34—6 .10—12 .2-4 .8—10 [30-2 Population percentage of the . B5 allele ->10