Locus control and developmental expression of human globin–complex genes

(a) The locus control region (LCR) of the human -globin complex contains four regulatory segments (HS1 to HS4). (b) The LCR regulates the expression of five genes (is an unexpressed pseudogene) in a developmental pattern matched to gestational age(a) The locus control region (LCR) of the human -globin complex contains four regulatory segments (HS1 to HS4). (b) The LCR regulates the expression of five genes (is an unexpressed pseudogene) in a developmental pattern matched to gestational age

(a) B-globin gene complex and LCR 0 10 20 30 4O 50 60 70 kb I I I I I I I I H54 H53 H52 H51 Ill-IIII— ‘83 6 LCR (b) Developmental expression of ,B-globin—complex genes % of total ,B-globin synthesis 61218243036 6 12 18 24 30 364248 Weeks of oestation Birth Weeks of aoe