The nurse explains to a student nurse the mechanism by which resistance to fluoroquinolones occurs. ...

Correct Answer: 2
Rationale 1: A change in bacterial cell wall permeability, the development of resistance pumps, and mutations to DNA gyrase contribute to resistance to fluoroquinolones.
Rationale 2: Fluoroquinolones do not bind with the enzyme DNA helicase. They bind with DNA gyrase, so resistance will occur from mutations to DNA gyrase.
Rationale 3: A change in bacterial cell wall permeability, the development of resistance pumps, and mutations to DNA gyrase contribute to resistance to fluoroquinolones.
Rationale 4: A change in bacterial cell wall permeability, the development of resistance pumps, and mutations to DNA gyrase contribute to resistance to fluoroquinolones.
Global Rationale: Fluoroquinolones do not bind with the enzyme DNA helicase. They bind with DNA gyrase, so resistance will occur from mutations to DNA gyrase. A change in bacterial cell wall permeability, the development of resistance pumps, and mutations to DNA gyrase contribute to resistance to fluoroquinolones.