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zcaballero zcaballero
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6 years ago
Describe the mechanism by which heterochromatin can spread, once it has been established in one region of the chromosome.
 
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6 years ago
Once the initial H3 lysine 9 methylation is established on core histone octamers in one region, the modification attracts a specific set of proteins and other histone-methylating enzymes. These enzymes create the same modification on adjacent histone octamers, which continue to recruit more heterochromatin-specific proteins and enzymes, creating a wave of heterochromatin spreading along the chromosome.
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