The researchers found that the patients died from SULT1C2 various causes will increase more than doubled risk patients with asymptomatic renal artery calcification, which is a separate independent of traditional cardiovascular risk factors and death associated risk factors. The researchers found that patients with asymptomatic renal artery calcification is more than double all-cause mortality, independent of traditional cardiovascular risk factors in a separate death-related risk factors.According to the research of Dr. DenaRifkin and colleagues from the University of California, San Diego, after adjustment for
SULT1E1 factors such as age, sex, diabetes and a family history of cardiovascular disease, adult mortality in patients with asymptomatic renal artery calcification (RAC), an increase of 63% (hazard ratio 1.63, 95% confidence interval 1.17 Dao 2.29).Mentioned in a research report in the online edition of the Journal of the American Heart Association, the risk remains elevated even in the correction of hypertension may be related to SULT2A1 factors (hazard ratio 1.44, 95% confidence interval 1.02to2. 03).Although people have coronary artery calcification and cardiovascular disease linked and the RAC can exist in patients with renal vascular disease, but whether the RAC is associated with mortality is still unknown."It is still unclear, renal artery calcification only prompt systemic vascular calcium overload, or as a separate danger signals."However, the renal artery calcium often appear together with other places of calcium in the vascular system and "it appears likely prompt a different and possibly more severe
SULT2B1 vascular calcification phenotype." They pointed out.
In order to clarify the relationship between the RAC and mortality, Rifkin's team observed a queue of 4450 cases of individuals not suffering from cardiovascular disease. Between 1999-2003, these patients added to the interest, or by their personal physician recommended in this
SUMO1 experiment, and an adjunct to this as their standard of preventive health care. The author explains. In order to clarify the relationship between the RAC and mortality Rifkin's group observed a queue of 4450 cases of individuals without cardiovascular disease. Between 1999-2003, these patients added to the interest, or by their personal physician recommended in this experiment, and an adjunct to this as their standard of preventive health care. The author explains.The participants underwent a whole body CT scan and physical examination and complete past history. Years of follow-up. (Median follow-up period of 8.2 years).Queue, 14% of individuals suffering from the RAC. Than not suffering RAC individuals, these patients age, associated with diabetes, systolic hypertension, and dyslipidemia.Of which there were 178 deaths, 41 patients died of cardiovascular causes.In univariate analysis, the mortality rate per thousand people in the RAC group annually 4.24, compared with non-the RAC disease group compared with per thousand per year 2.3. The authors note With RAC graded higher age-adjusted mortality significantly with an increasing trend (P <0.001).After adjustment for age and sex, the RAC all-cause mortality in patients with elevated 76%. (Hazard ratio 1.76,95% confidence interval 1.26 to 2.45).Calcification of the renal vascular bed outside corrected, the risk is still increased 40% (hazard ratio 1.40,95% confidence interval from 0.99 to 1.97).Conversely, cardiovascular mortality (hazard ratio 0.95, 95% confidence interval 0.48 Dao 1.88) does not rise after the correction, the few number of cases of death may be associated with heart related."Perhaps the emergence of RAC makes patients more susceptible to hemodynamic abnormalities, and it is difficult to survive in non-cardiac diseases, which may explain the RAC patients significantly improved all-cause mortality." The researchers noted.
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