Nursing responsibilities when giving osmotic diuretics include which of the foll

1,2,3 -- Osmotic diuretics commonly used are mannitol and urea (Ureaphil), which pull extracellular water into the vascular system and increase the glomerular filtration rate (GFR). They are given intravenously and mannitol solution should be checked for crystallization prior to administration. A test dose may be given and urine output is evaluated for an adequate response. The patient should be assessed for signs of worsening heart failure because of the increased vascular volume that occurs with these medications. Orthostatic hypotension is not an issue due to the increase in intravascular volume but should be assessed when giving loop diuretics. Ototoxicity is a concern with high doses of loop diuretics.