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Home Q & A Board Biology-Related Homework Help General Biology
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dlwldk17 dlwldk17
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7 years ago
the question is : Phosphofructokinase is considered to be the enzyme responsible for controlling the rate-limiting step of the glycolytic pathway.  Why would this step be considered rate-limiting step?  Explain with reference to the feedback mechanisms that are occurring in cell respiration.
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#1
Staff Member
7 years ago
Phosphofructokinase (PFK) is the enzyme that controls the third step of glycolysis, the conversion of fructose-6-phosphate (F6P) into fructose-1,6-biphosphate (F1,6BP). It works by transferring a phosphate group from ATP to F6P. This is the slowest reaction in glycolysis and therefore is the rate-limiting step.
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#2
Educator
7 years ago
I've never heard of it as the "slowest".

It's the rate limiting step because it is controlled via negative feedback
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