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Home Q & A Board Biology-Related Homework Help Cell Biology
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barry barry
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10 years ago
How does allelic exclusion prevent multiple heavy-chain rearrangements from occurring in pre-B cells?

A.   RAG1 and RAG2 are down-regulated, and TdT activity is lost so that no additional heavy-chain rearrangements may take place.
B.   RAG1 is up-regulated while RAG2 and TdT are down-regulated to prevent heavy-chain recombination on the second set of chromosomes.
C.   RAG1 and RAG2 induce silencing of the second alleles for VH-DJH rearrangement.
D.   TdT initiates light-chain rearrangement.
E.   TdT releases a cytokine to trigger apoptosis in the pre-B cell.
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padrepadre
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10 years ago
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barry Author
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#2
10 years ago
Thanks.
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