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Mycobacterium leprae, the causative agent of leprosy in humans, is an intracellu

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Mycobacterium leprae, the causative agent of leprosy in humans, is an intracellu

Mycobacterium leprae, the causative agent of leprosy in humans, is an intracellular pathogen that resides in the phagosome of macrophages. Leprosy presents in two main clinical manifestations. Tuberculoid leprosy results in the formation of granulomas and a cell-mediated immune response while lepromatous leprosy results in the production of high levels of IgG (hypergammaglobulinemia). If TH2 is produced in high levels during an M. leprae infection, which type of leprosy would result?

A.   Lepromatous leprosy
B.   Tuberculoid leprosy
C.   Either lepromatous leprosy or tuberculoid leprosy
D.   Neither one; leprosy depends on the expression of TREG cells
E.   Cannot determine; insufficient clinical evidence to support either outcome

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