A client has been started on a first-generation nonsteroidal anti-inflammatory medication for ...

Correct Answer: 2
Rationale 1: The adverse effects of Celebrex are not dose dependent.
Rationale 2: Celecoxib (Celebrex) is an effective second-generation NSAID but has limited use due to increased risk of myocardial infarction and stroke.
Rationale 3: Celebrex is still available, but its use is limited due to the increased risk of myocardial infarction and stroke.
Rationale 4: Use of Celebrex is limited due to the increased risk of myocardial infarction or stroke.
Global Rationale: Celecoxib (Celebrex) is a second-generation NSAID and is the sole drug remaining in this class in the United States. Other COX-2 inhibitors are still available outside the U.S. The COX-2 inhibitors have been found to increase the risk of serious cardiovascular events, including fatal MI and stroke. These results are not dose dependent.