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colleen colleen
wrote...
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Posts: 17076
12 years ago
Explain how fatty acids are activated in the cytoplasm and ultimately transported into the mitochondrion to be oxidized. Why would the use of carnitine be an advantage for this process?
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wrote...
12 years ago
Fatty acids are activated by adding CoA to the molecule, which also requires the hydrolysis of a molecule of ATP (mediated by fatty acyl-CoA ligase (also called acyl-CoA synthetase or thiokinase). For entry into the mitochondrion, the CoA is exchanged for carnatine by carnatine transferase I. The fatty acyl-carnitine intermediate is then transported inside the membrane of the mitochondrion, where the reverse reaction takes place using an exchange by carnitine palmitoyl transferase II. The fatty acyl-CoA is now available for oxidation. 
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