The nurse is caring for a client who is receiving doxorubicin (Adriamycin). Which serious adverse ...

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Rationale 1: The most serious dose-limiting adverse effect of doxorubicin is delayed cardiac toxicity that can result in irreversible heart failure.
Rationale 2: Hair loss is a side effect but not a serious adverse effect.
Rationale 3: Vomiting is a side effect but not a serious adverse effect.
Rationale 4:Secondary malignancies may occur 13 years following therapy. This needs to be assessed later.

Global Rationale: The most serious dose-limiting adverse effect of doxorubicin is delayed cardiac toxicity that can result in sinus tachycardia, bradycardia, delayed heart failure, acute left ventricular failure, and myocarditis.