The nurse is caring for a client who has not responded well to other treatments for heart failure. ...

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Rationale 1: Phosphodiesterase inhibitors are used for only 23 days when other drugs have failed.
Rationale 2: Because of their toxicity, phosphodiesterase inhibitors are reserved for patients who have not responded to ACE inhibitors or cardiac glycosides, and they are generally used only for 23 days.
Rationale 3: Phosphodiesterase inhibitors are used for only 23 days when other drugs have failed.
Rationale 4: Phosphodiesterase inhibitors are used for only 23 days when other drugs have failed.

Global Rationale: Because of their toxicity, phosphodiesterase inhibitors are reserved for patients who have not responded to ACE inhibitors or cardiac glycosides, and they are generally used only for 23 days.