The nurse would anticipate an alteration in drug excretion in clients with which conditions? 1. ...

Correct Answer: 1,2
Rationale 1: Any condition which decreases or impairs glomerular filtration rate will decrease excretion of drugs from the body.
Rationale 2: Glomerular filtration rate is directly related to cardiac output. Any heart disease that decreases cardiac output will decrease excretion of drugs from the body.
Rationale 3: The quick transit of medication through the small intestines alters absorption, not metabolism.
Rationale 4: The lungs do not metabolize drugs.
Rationale 5: Alzheimer disease will not affect the metabolism of drugs.
Global Rationale: Any condition which decreases or impairs glomerular filtration rate will decrease excretion of drugs from the body. Glomerular filtration rate is directly related to cardiac output. Any heart disease that decreases cardiac output will decrease excretion of drugs from the body. The quick transit of medication through the small intestines alters absorption, not metabolism. The lungs do not metabolize drugs. Alzheimer disease will not affect the metabolism of drugs.