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goatMaster goatMaster
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6 years ago
What characteristic of Prader-Willi syndrome is not a characteristic of Angelman syndrome?
 
  a. It is inherited from the father.
  b. Mental retardation is observable.
  c. Imprinting of an abnormal chromosome 15.
  d. Seizure disorder is present.
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wrote...
6 years ago
ANS: A
A well-known disease example of imprinting is associated with a deletion of about 4 million base (Mb) pairs of the long arm of chromosome 15. When this deletion is inherited from the father, the child manifests Prader-Willi syndrome, whose features include short stature, hypotonia, small hands and feet, obesity, mild to moderate mental retardation, and hypogonadism. The same 4 Mb deletion, when inherited from the mother, causes Angelman syndrome, which is characterized by severe mental retardation, seizures, and an ataxic gait.
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