A 51-year-old woman has been experiencing signs and symptoms of perimenopause and has sought help ...

A 51-year-old woman has been experiencing signs and symptoms of perimenopause and has sought help from her family physician.
 
  A deficiency in estrogen levels has been determined to be a contributing factor. Which of the following phenomena could potentially underlie the woman's health problem?
  A)
  Sufficient synthesis of estrogen but inadequate vesicle-mediated release
  B)
  Inadequate synthesis in the rough endoplasmic reticulum of her ovarian cells
  C)
  Insufficient estrogen production within the smooth endoplasmic reticulum of the relevant cells
  D)
  A lack of prohormone precursors needed for estrogen synthesis and release