two types of sites at a motor end plate

Nicotinic Acetylcholine receptors (taregt cell), which are ligand gated ion channels, and presynaptic nicotinic acetylcholine receptors.

Acetylcholine diffuses into the synaptic cleft and binds to the nicotinic acetylcholine receptors bound to the motor end plate.

These receptors are ligand-gated ion channels, and when they bind acetylcholine, they open, allowing sodium ions to flow in and potassium ions to flow out of the muscle's cytosol. Because of the differences in electrochemical gradients across the plasma membrane, more sodium moves in than potassium out, producing a local depolarization of the motor end plate known as an end-plate potential (EPP).

The presynaptic nicotinic acetylcholine receptors are used for the reuptake of any aceylcholine that is not used.