Which of the following type of reversible enzyme inhibitor binds to a site distinct from the substrate active site?
A. competitive
B. uncompetitive
C. mixed
D. uncompetitive and mixed
E. competitive, uncompetitive, and mixed
Three disadvantages of utilizing microarrays for transcriptome analysis are that microarrays (select all correct choices):
A. require large quantities of RNA to hybridize and thus show a positive signal.
B. show high levels of nonspecific (background) hybridization.
C. may not have DNA to which specific RNAs will hybridize.
D. will not allow comparison of transcription between cell types.
E. do not accurately report transcriptional levels of specific mRNAS.
F. are not able to detect and evaluate rare allele variant transcripts.
Which of the following is true of the trombone model of replication?
A. As Okazaki fragments are extended by Pol I, the loop in the DNA template grows.
B. Once an Okazaki fragment is completed, the clamp is ejected.
C. A loop is formed in one strand of the template DNA to allow 5'-3' synthesis of the leading strand.
D. When a new clamp is loaded, primase is triggered to synthesize a primer.
E. Binding of the polymerase core to a new primer/template complex triggers loading of the clamp.
Which of the following type of reversible enzyme inhibitor always lowers the measured Km of the enzyme it binds?
A. competitive
B. uncompetitive
C. mixed
D. uncompetitive and mixed
E. competitive, uncompetitive, and mixed
The site-specific recombination reaction outcome depends on the location and orientation of the target sites. Which of the following is a possible outcome?
A. Recombination between two oppositely oriented sites on the same DNA molecule will result in a deletion.
B. Recombination between two oppositely oriented sites on the same DNA molecule will result in an inversion.
C. Recombination between two oppositely oriented sites on the same DNA molecule will result in an insertion.
D. Recombination between two sites oriented in the same direction on the same DNA molecule will result in an inversion.
E. Recombination between two sites oriented in the same direction on different DNA molecules will result in a deletion.
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