To freedom, according to the German breast group (German BIRADS Group) Registry data show that ANXA6 during pregnancy women diagnosed with breast cancer to standard chemotherapy regimens will not endanger the health of the fetus after 12 weeks of gestation.Women delivered newborns undergoing chemotherapy, 121 cases of pregnancy compared with 36 cases of women receiving chemotherapy during pregnancy is not delivered newborns, fetal outcome no significant differences. The results at the European Breast Cancer Conference ANXA7 in the form of a poster display."Breast cancer is one of the most common cancer diagnosis during pregnancy," the first author, Frankfurt, Germany, Johann Wolfgang Goethe University, Dr Sibylle Loibl said. In, about 3 percent of all breast cancer patients have been diagnosed during pregnancy.
She explained: "In 2003, we developed the first international guidelines on the treatment of breast cancer during pregnancy (Cancer 2006; 106:237-46), and at the same time, we found that ANXA8 such data is very limited, we must be collected in this regard more information. "April 2003 to October 2008, German database Communist China, registered 235 cases of gestational breast cancer patients. The thrust of the researchers in the four weeks after the birth of the evaluation of fetal prognosis; In this study, ANXA9 also plans to make evaluations in the five years after treatment, the prognosis of children and their mothers.
The median age of these women was 33 years (range: 24 to 46 years). 23.8% of women diagnosed with breast cancer time for the first trimester, respectively, 39.5% and 36.8% of women in the second trimester and third trimester of pregnancy diagnosis.A total of 121 cases of AP2M1 women during pregnancy received cytotoxic chemotherapy.Majority of anthracycline therapy (58.6%), 16.5% of the FEC schemes (5 - fluorouracil, epirubicin and cyclophosphamide), and 14% of the CMF regimen (cyclophosphamide, methotrexate and 5 - fluorouracil). These patients the median cycle of chemotherapy during pregnancy acceptable number.
Pregnancy diagnosed with breast cancer in women, the majority (57.1%) for T2 tumors, 25.8% for T3 tumors, 11.5% for T1 tumors, 4.4% for T4 tumors. About half of the lymph node-positive tumors, 7.9% of the transfer (M1). Nearly 2/3 (63.5%), breast cancer is estrogen receptor negative, 34.8% to detect HER2-positive. Most of the tumors (93.4%) was recorded as invasive ductal carcinoma, or other.
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