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A client has developed heparin-induced thrombocytopenia (HIT). While planning an explanation of this ...

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A client has developed heparin-induced thrombocytopenia (HIT). While planning an explanation of this ...

A client has developed heparin-induced thrombocytopenia (HIT). While planning an explanation of this disorder for the client, the nurse considers which pathophysiology?
1. Activation of cytokines (such as interleukins) by heparin resulting in inappropriate activation of the coagulation cascade
2. Formation of platelet-heparin-PF4 complexes that trigger increased levels of fibrinogen in the blood
3. Activation of platelets by heparin-Fc receptor complexes resulting in prothrombotic activity
4. Formation of antibody-heparin-PF4 complexes with subsequent activation of platelets by the antibody portion of the complexes

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High-Acuity Nursing

Edition: 6^th

Authors: Wagner, Hardin-Pierce

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