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Fluoroquinolones are known to be effective against both gram-negative and gram-positive organisms. H

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Fluoroquinolones are known to be effective against both gram-negative and gram-positive organisms. H

Fluoroquinolones are known to be effective against both gram-negative and gram-positive organisms. How is this possible?
1. Fluoroquinolones that are effective against gram-negative organisms block the enzyme topoisomerase IV, which stops the migration process of the two new strands to opposite sides of the cell.
2. Fluoroquinolones that are effective against gram-positive organisms block the enzyme DNA gyrase, which stops relaxation of the supercoil of the DNA.
3. Fluoroquinolones that are effective against gram-negative organisms block the enzyme DNA gyrase, and those effective against gram-positive organisms block topoisomerase IV.
4. All fluoroquinolones are effective against both gram-negative and gram-positive organisms. There is no difference in the way they block bacterial DNA replication.

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Pharmacology: Connections to Nursing Practice

Edition: 3^rd

Authors: Adams, Urban

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First-year pharmacology student, representing MIT!

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9 years ago

Sounds and feels right, thank you for the rationale.

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First-year pharmacology student, representing MIT!

ngin

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9 years ago

I've studied this stuff recently, so I knew what the answer was. Good luck with the rest.

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