High doses of vitamin D(?800iu/day)may be effective in preventing hip fractures

With the increase in the proportion of the elderly population,fractures in the elderly.It is estimated that about 75%of the fracture in the PFN4 elderly over the age of 65,in 2050,the incidence of fractures in the elderly may increase to more than double the incidence of.From daily life to take precautionary measures to some extent alleviate the fracture of the elderly patients is a more difficult task.Treatment strategies are usually taken in the past,orthopedic surgeons recommend that elderly patients with adequate supplementation of vitamin D,but the existing evidence-based PG medicine studies have shown that vitamin D supplementation on fracture prevention in elderly patients and there is no practical significance.But limited to the study of various design methods and data collection gaps,these conclusions are still more controversy.To further clarify the added vitamin D fracture prevention for the elderly,scholars from the University of Zurich,Switzerland,the evidence-based PGAM1 medicine analysis of the published conclusions,and phase research papers published in the authoritative Journal of Medicine NEJM recently published.

By retrieving database,the researchers were included in 11 randomized,double-blind case-control study,a total of 31 022 subjects,average age 76 years,approximately 91%of subjects were female.The 11 studies of the study population will be classified into the PGC crowd to complement the subjects of different doses of vitamin D for the experimental group and control group,experimental group,regardless of peacetime joint calcium supplementation,the control group for the crowd by vitamin D supplementation The test persons(regardless of the patients whether the supplementary calcium).Relevant demographic data in Table 1.Events of the study end point for fractures of the hip PGD fracture and non-pyramidal,the correlation analysis by COX regression analysis,the supplement of vitamin D dose,and population age,gender,residence type,and other relevant factors.The study included of 31 022 in subjects 1111,hip fracture,3770,non-cone fractures(Table 2).Vitamin D supplementation and control groups,the incidence of hip fracture decreased by 10%,rather than the cone fractures decrease the incidence of 7%,between the two groups no significant difference.Classification comparison supplementary dose of vitamin D supplement of patients with high doses of vitamin D(average 800iu/,792-2000iu/day),hip fracture incidence decreased by 30%,rather than the cone parts the incidence of fractures decreased by 14%,and the control group was significant difference.Factors analysis of differences in population age,gender,type of residence,the basis of 25-hydroxyvitamin D levels,taking calcium,remained significant.