Chronic hepatitis B than chronic hepatitis C lead to the risk of death

Chronic hepatitis B (CH-B) vs. chronic hepatitis C (CH-C) infection will bring the risk of RAB1A liver-related death, the medical profession is not yet clear. The U.S. University of infectious disease Research this multi-center AIDS Cohort Study (MACS) compared liver-related mortality in the above two groups, they found that chronic hepatitis B than chronic hepatitis C cause liver-related RAB1B death risk higher, especially for immunocompromised HIV-infected population. Related papers published in the online edition of CID magazine in July 2012 a.The MACS study included 680 CH-B (n = 337) or CH-C (n = 343) infection, is expected to follow-up to patient death, or until March 30, 2010. 472 patients (69.4%) of HIV-1 infection. The cause of death from the death registration or death certificate. The researchers used a Poisson regression analysis of RAB21 liver-related mortality and total factor mortality rates (MRs) and the correction for potential confounding factors and competing risks.The results showed that follow-up of 6728 person-years (PYs), there were 293 cases of factors deaths (43.5 per 1000 PYs), of which 51 cases of liver disease (7.6 per 1000 PYs). The researchers found similar factor caused by the CH-B and CH-C MR; However, the former (9.6 per 1000 PYs; 95% confidence interval [CI], 6.9-13.2) lead to liver MR statistically significantly RAB22A higher than (5.0 per 1000 PYs; 95% CI, 3.0-8.4). 46 cases of liver-related deaths (90.2%) of HIV-infected subgroup, even if it is a correction for potential confounding factors (incidence, 2.2; P = .03), and competitive risk (sub-hazard ratio, 2.4; P = .02) CH-B-induced Rab23 liver MR incidence is still higher than the CH-C. More importantly, for the HIV-infected people with CD4 cell count> 350 cells/mm3 compared with those who, CD4 cell count <200 cells/mm3 by the risk of liver-related deaths, 16.2 times more (95% compared to CI, 6.1-42.8).

Researchers to conclude that chronic hepatitis B than chronic hepatitis C leads to a higher risk of liver-related death, especially for immunocompromised HIV-infected population.