RNA polymerase and RNA transcription fidelity
http://7thspace.com/headlines/343669/stepwise_mechanism_for_transcription_fidelity.htmlRNA polymerase works with TFIIS to transcribe RNA true to the DNA sequences
http://www.pnas.org/content/93/24/13677.abstractRNA intron removal & exon splicing has a means to determine incorrect intron lariats. The spliceosomal ATPase Prp16 assists with fidelity of splicing RNA.
http://www.ncbi.nlm.nih.gov/pubmed/8324826http://molbio.bsd.uchicago.edu/Faculty_and_Research/01_Faculty_Alphabetically.php?faculty_id=157http://www.nature.com/nsmb/journal/v13/n6/full/nsmb0606-472.htmlResearch is ongoing to determine the ribosomes editor/proofreading mechanism for detecting incorrect tRNA insertions and aborting the protein in progress. Dr Green says, "in the event of miscoding, the ribosome cuts the bond and aborts the protein-in-progress"
http://www.sciencedaily.com/releases/2009/01/090107134529.htmhttp://www.ncbi.nlm.nih.gov/pubmed/6348473The central dogma is that the sequences are copied to RNA and translated to protein in a sequence specific manner in one direction only; DNA -> RNA -> protein. There is no mechanism to read the sequences of the amino acids, create an RNA from this reading and move this back into the nucleus to reverse transcribe into DNA.
http://en.wikipedia.org/wiki/Central_dogma_of_molecular_biologyReverse transcription RNA -> DNA does exist in RNA viruses but due to the degeneracy of the code there is no way to read amino acid residues and know which of the alternate codes to use to get the original sequence. Only methionine and tryptophan have single codons the rest have multiple so this offers no way to check for errors in the RNA.
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