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lexiie lexiie
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11 years ago
What is the difference between blood type B positive and blood type B negative? Why cant blood type A positive donate to blood type A negative?
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wrote...
11 years ago
It's caused by the Rh factor. It's actually quite complicated to explain, involving 30 antigens of which D, C, c, E and e are the most important. Basically, if an individual has the Rh factor, they are blood type "positive" and if they don't have the Rh factor, then they're blood type "negative."
You can try and decipher the exact meaning, but the basic explanation is probably all that's necessary.
wrote...
11 years ago
The presence of the Rh antigen on the erythrocyte surface makes a person Rh+ (have it) or Rh- (don't have it);  whether someone is Rh+ or Rh- is detemined by a single gene on chromosome #1.  It has nothing to do with ABO blood groups, though certain combinations are rarer than others (AB- is pretty uncommon, A+ is very common).

A+ can donate to A-, but just once, since the first exposure to A+ will initiate an immune response;  cross-matching is only done in emergencies.
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