A three-generation pedigree is constructed around the designated “index” patient

A three-generation pedigree is constructed around the designated “index” patient. The term proband means:
1. The “index” patient has the disorder of interest.
2. One parent of the “index” patient has the disorder of interest.
3. The “index” patient does not have the disorder of interest.
4. Siblings of the “index” patient do not have the disorder of interest.
Correct Answer: 1
Rationale 1: The proband indicates that the “index” patient has the disorder of interest. A consultand is an “index” patient seeking genetic counseling for a disorder she is not affected by at present.
Rationale 2: The proband indicates that the “index” patient has the disorder of interest. A consultand is an “index” patient seeking genetic counseling for a disorder she is not affected by at present.
Rationale 3: The proband indicates that the “index” patient has the disorder of interest. A consultand is an “index” patient seeking genetic counseling for a disorder she is not affected by at present.
Rationale 4: The proband indicates that the “index” patient has the disorder of interest. A consultand is an “index” patient seeking genetic counseling for a disorder she is not affected by at present.