Identify and describe a drug used to treat a microbial infection by targeting the microbe's DNA.?

INHIBITION OF NUCLEIC ACID SYNTHESIS
Differences between the enzymes used to synthesize nucleic acids in prokaryotes and eukaryotes provide the means for selective action of antibiotics that take their effect by inhibiting nucleic acid synthesis. Antibiotics of the rifamycin family inhibit RNA synthesis because they bind to RNA polymerase, which is responsible for transcribing bacterial DNA to RNA. Antibiotics of the quinolone group interfere with DNA gyrase, the enzyme responsible for unwinding DNA in preparation of replication.