Integral Membrane Protein

There is an integral membrane protein that is like the one shown in the attached document.

Show how this protein was inserted into the ER membrane so as to give the structure
in the diagram above. Start with the mRNA already bound to a ribosome at the beginning of translation. Use diagrams and/or text to describe how this protein becomes an IMP of the endoplasmic reticulum membrane. The diagram indicates the protein’s orientation in the plasma membrane. Do not discuss how the protein gets from the ER to the PM. Discuss just how it gets into the ER membrane in the orientation in the figure.

“COOH” means carboxy terminus; “NH2” means amino terminus; the three squiggles are transmembrane domains; the wavy lines above and below the membrane are the extracellular and cytosolic domains; the two parallel straight lines represent the outer and inner surfaces of a bilayer membrane; the things with one head and two legs represent a few of the lipid molecules that constitute the PM.