× Didn't find what you were looking for? Ask a question
Top Posters
Since Sunday
r
5
m
5
h
5
r
5
t
5
B
5
P
5
s
5
m
5
c
5
c
4
4
Home Q & A Board Biology-Related Homework Help Anatomy and Physiology
New Topic  
Istahil Istahil
wrote...
Posts: 3
Rep: 0 0
10 years ago
When patients who are receiving glucocorticoid therapy (for example, with prednisone) need to stop taking it, the doctor will prescribe a series of doses of tapering size to gradually lower the dose rather than suddenly stop it. Explain this dosage strategy in terms of the negative feedback control of cortisol secretion.
Read 448 times
1 Reply

Related Topics

Replies
wrote...
#1
Staff Member
Educator
10 years ago
Steroid treatment for longer than 10 days (as customary) is supposed to suppress the HPA axis - hypothalamus-pituitary-adrenal. in order to avoid an Addisonian crisis (which is a central adrenal deficiency) the tapering strategy allows for the gradual reactivation of the HPA axis.

Also see: https://biology-forums.com/index.php?topic=76959.msg213548#msg213548
Mastering in Nutritional Biology
Tralalalala Slight Smile
New Topic      
Quick Reply
Explore
Post your homework questions and get free online help from our incredible volunteers
  878 People Browsing
Start New Topic Take the Tour CoursesNew Study Tools Topics Trending Browse by Textbook
Live Chat
Related Images
  
 546
  
 387
  
 236