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Home Q & A Board Biology-Related Homework Help Anatomy and Physiology
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Istahil Istahil
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10 years ago
When patients who are receiving glucocorticoid therapy (for example, with prednisone) need to stop taking it, the doctor will prescribe a series of doses of tapering size to gradually lower the dose rather than suddenly stop it. Explain this dosage strategy in terms of the negative feedback control of cortisol secretion.
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10 years ago
Steroid treatment for longer than 10 days (as customary) is supposed to suppress the HPA axis - hypothalamus-pituitary-adrenal. in order to avoid an Addisonian crisis (which is a central adrenal deficiency) the tapering strategy allows for the gradual reactivation of the HPA axis.

Also see: https://biology-forums.com/index.php?topic=76959.msg213548#msg213548
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